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急性白血病是儿童最常见的恶性肿瘤之一。儿童急性白血病分急性淋巴细胞白血病和急性非淋巴细胞白血病 ,其中前者占 70 %。儿童急性淋巴细胞白血病 ( ALL)在发达国家 5年以上的无事故生存 ( EFS)率达 80 % ,我国北京儿童医院和上海儿童医学中心的 EFS也达到 75 %左右。但是 ,我国绝大多数医院小儿 ALL的 EFS只有 1 0 %～ 5 0 % ,有的甚至更低。如何进一步提高我国小儿 ALL的 EFS,成为新世纪的一项重要任务。为此 ,本刊特邀请解放军总医院吕善根教授组织和主持了本期的有关小儿 ALL的笔谈讨论。 1 3位国内专家对此发表许多高见 ,希望通过这次笔谈讨论 ,抛砖引玉 ,能起到促进提高我国小儿 ALL的 EFS水平的作用 ,造福于儿童。
Acute leukemia is one of the most common malignancies in children. Children with acute leukemia sub-acute lymphoblastic leukemia and acute non-lymphocytic leukemia, of which the former accounted for 70%. Children with acute lymphoblastic leukemia (ALL) in developed countries more than 5 years of accidental survival (EFS) rate of 80%, China’s Beijing Children’s Hospital and Shanghai Children’s Medical Center also reached about EFS 75%. However, most hospitals in our country pediatric ALL EFS only 10% ~ 50%, and some even lower. How to further improve the EFS of pediatric ALL has become an important task in the new century. To this end, the magazine invited Professor Lu Shangen, PLA General Hospital organized and presided over this issue of Pediatric ALL’s written discussion. A total of three domestic experts made many suggestions on this issue and hope that through this discussion and discussion, they will be able to promote the EFS level of pediatric ALL in our country and bring benefits to children.