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28例晚期消化道恶性肿瘤腹腔转移患者随机被选入单纯静脉化疗组(对照组,n=14)和静脉化疗+腹腔热灌注+射频透热组(热疗组,n=14),比较两组的疗效及不良反应发生情况。结果:热疗组的有效率为85.7%,对照组为64.2%,两组相比,差异有统计学意义(P<0.05);两组的不良反应均较轻(以Ⅰ~Ⅱ级为主)。结果表明,静脉化疗+腹腔热灌注+射频透热联合治疗可明显提高晚期消化道恶性肿瘤腹腔转移的治疗效果。
Twenty-eight patients with peritoneal metastases of advanced gastrointestinal malignancies were randomly enrolled in the simple intravenous chemotherapy group (control group, n = 14) and intravenous chemotherapy + intraperitoneal hot perfusion + radiofrequency diathermy group (hyperthermia group, n = 14) Group efficacy and adverse reactions occurred. Results: The effective rate of hyperthermia group was 85.7%, while that of control group was 64.2%. There was significant difference between the two groups (P <0.05). The adverse reaction was mild in both groups ). The results showed that intravenous chemotherapy combined with intraperitoneal hot perfusion + radiofrequency diathermy can significantly improve the therapeutic effect of peritoneal metastases of advanced gastrointestinal malignancies.