Whipple病属少见病,近年文献报道渐见增多,至今共300余例.国内仅报导一例.现就此病研究的近期发展作一综述.病理肉眼及光镜所见病变主要累及十二指肠和近端空肠,远端病变减轻.肠壁增厚、水肿,粘膜呈粉红或红色天鹅绒状,密布淡黄色或黄白色小颗粒.空肠 Whipple disease is a rare disease, the literature reports in recent years, gradually increased, so far a total of more than 300 cases.Report only one case.There is a review on the recent development of this disease research.Pathological and optical microscopic lesions mainly involving the duodenum and Near the jejunum, distal lesion reduced. Intestinal wall thickening, edema, mucosa was pink or red velvet, dense yellowish yellow or white particles.