癫痫持续状态后海马常有齿状回和门区的颗粒细胞增生及异位,而且新生颗粒细胞兴奋性明显增高,并与海马穿通路径纤维、出芽的苔藓纤维回返支等形成广泛的突触联系和突触改建;同时伴有多部位和不同程度的主细胞和中间神经元的丢失,而且抑制性中间神经元的功能也降低。故异常的颗粒细胞增生和突触改建以及抑制性中间神经元的丢失对癫痫自发性再发作的形成产生明显影响。 Hippocampus hippocampus often have proliferative and ectopic granulosa cells in the dentate gyrus and portal area, and the excitability of neonatal granulosa cells is obviously increased, and extensive synaptic connections are formed with the hippocampal punch-through pathways and the sprouting mossy fiber return branch. And synaptic remodeling; at the same time, there are many parts and different degrees of loss of the main cells and interneurons, and the function of the inhibitory interneurons is also reduced. So abnormal granulosa cell proliferation and synaptic alterations and the loss of inhibitory interneurons have a significant impact on the formation of spontaneous reemergence of epilepsy.