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本文研究了８名健康志愿者静脉滴注８０ｍｇ奥美拉唑药代动力学和临床药效学。方法：血药浓度测定采用ＨＰＬＣ方法，２４ｈ胃内ｐＨ监测采用Ｄｉｇｉｔｒａｐｐｅｒ ＭＫ Ⅲ动态 ｐＨ监测仪。结果：奥美拉唑药－时曲线符合二室开放模型， ８名受试者 ２４ ｈ基础胃酸ｐＨ平均为 ２．３０±０．７４， ｐＨ＞ ４总时间百分比为１６．６７％ ±１１．９７％；静脉滴注 ８０ｍｇ奥美拉唑后， ２４ ｈ胃内 ｐＨ平均值和 ｐＨ＞ ４总时间百分比分别升至５．５７±０．９３和８１．０７％±１５．７５％（Ｐ＜０．０１）。结论：结果表明静脉滴注８０ｍｇ奥美拉唑可显著抑制胃酸分泌，但血药浓度与抑酸作用程度不相关。
This study investigated the pharmacokinetics and clinical pharmacodynamics of 80 mg omeprazole in eight healthy volunteers. Methods: HPLC method was used to determine plasma concentration. 24h gastric pH monitoring was performed with Digitrapper MK Ⅲ dynamic pH monitor. RESULTS: The omeprazole-time curve was in accordance with the two-compartment open model. The basal gastric acid pH of 24 hrs averaged 2.30 ± 0.74 in 8 subjects and 16.67% ± 11 in pH> 4. 97%. After 80 mg intravenous infusion of omeprazole, the average intragastric pH and the total time of pH> 4 increased to 5.57 ± 0.93 and 81.07% ± 15.75% (P < 0.01). Conclusion: The results showed that intravenous 80mg omeprazole can significantly inhibit gastric acid secretion, but the plasma concentration and the role of acid suppression is not related.