酒精性脂肪肝大鼠血清TNF-α、IL-8水平的变化

来源 :中国基层医药 | 被引量 : 0次 | 上传用户:gift19852003
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目的 观察酒精性脂肪肝大鼠血清TNF-α、IL-8水平的变化.方法以10%酒精加高脂饲料喂饲10周,造成大鼠酒精性脂肪肝模型,取血清测丙氨酸氨基转移酶(ALT)活性,放免法测定血清TNF-α、IL-8含量,处死大鼠,取肝组织做病理学检查.结果模型组大鼠肝组织出现不同程度的肝脂肪变性,血清中ALT活性、TNF-α、IL-8含量较正常组明显升高,差异有显著意义(P<0.05~0.01).结论血清TNF-α、IL-8水平的升高可能是酒精性脂肪肝发生的重要机制之一。

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