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目的 :研究男性内源性性激素与冠心病 (CHD)之间的关系。方法 :用放射免疫法测定了 4 5例经冠状动脉造影证实有 1支以上主要冠状动脉狭窄≥ 5 0 %的男性CHD患者和 4 0例同期同年龄健康男性对照者的血清雌二醇 (E2 )、睾酮 (T)、脱氢表雄酮 (DHEA)及硫酸脱氢表雄酮 (DHEAS)的水平。结果 :①CHD组血清DHEA、DHEAS的水平明显低于对照组 (分别为P <0 .0 5 ,P <0 .0 1) ,对总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白A、B(apoA、apoB)、脂蛋白a〔Lp(a)〕、体重指数 (BMI)进行协方差分析后 ,两组差异仍有显著性意义 (分别为P <0 .0 5 ,P <0 .0 1)。②在两组中血清E2 、T、E2 /T值的水平没有明显的区别。结论 :DHEA、DHEAS水平的降低可能是男性CHD的危险因子 ,并独立于其他几种已知的CHD的危险因素而存在
Objective: To study the relationship between male endogenous sex hormones and coronary heart disease (CHD). Methods: Serum estradiol (E2) was measured by radioimmunoassay in 45 male CHD patients with coronary artery stenosis ≥50% confirmed by coronary angiography and 40 healthy male controls of the same age at the same period ), Testosterone (T), DHEA and DHEAS. Results: ① The levels of serum DHEA and DHEAS in CHD group were significantly lower than those in control group (P <0.05, P <0.01), and the levels of total cholesterol (TC), triglyceride (HDL C), low density lipoprotein cholesterol (LDL C), apolipoprotein A, B (apoA, apoB), lipoprotein a [Lp (a)] and body mass index (BMI) There was still significant difference between the two groups (P <0.05, P <0.01, respectively). ② There was no significant difference between the two groups in the levels of E2, T, E2 / T. Conclusions: Decreased levels of DHEA and DHEAS may be risk factors for CHD in men and exist independently of risk factors for several other known CHDs