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目的观察中药免疫2号颗粒对高效抗转录病毒疗法(HAART)后免疫重建不全艾滋病患者的免疫重建效果。方法将361例HAART后免疫重建不全的艾滋病患者随机分为治疗组189例和对照组172例,分别采用免疫2号颗粒+HAART(治疗组)和免疫2号颗粒模拟剂+HAART(对照组)治疗72周,并于治疗前及治疗后12、24、36、48、60、72周时检测两组患者CD4+、CD45RA、CD45RO淋巴细胞绝对值计数。结果治疗后两组患者CD4+淋巴细胞计数绝对值均较治疗前升高(P<0.05),且治疗72周时治疗组明显高于对照组(P<0.05)。随着治疗周期的延长两组患者CD45RA淋巴细胞计数、CD45RO淋巴细胞计数均呈上升趋势(P<0.05);治疗72周时治疗组CD45RA淋巴细胞计数上升更明显(P<0.05),CD45RO淋巴细胞计数两组比较差异无统计学意义(P>0.05)。结论免疫2号颗粒能增加HAART后免疫重建不全艾滋病患者的CD4+淋巴细胞数量,从而改善机体免疫力。
Objective To observe the immune reconstitution effect of traditional Chinese medicine Immunization Particle 2 on patients with AIDS with immunodeficiency syndrome after high-activity anti-retroviral therapy (HAART). Methods A total of 361 AIDS patients with incomplete immune reconstruction after HAART were randomly divided into treatment group (n = 189) and control group (n = 172). Immunization with Particle 2 + HAART and Immunization with Particle Simulator HAART (control group) After 72 weeks of treatment, the absolute counts of CD4 +, CD45RA and CD45RO lymphocytes in both groups were measured before treatment and at 12, 24, 36, 48, 60 and 72 weeks after treatment. Results After treatment, the absolute value of CD4 + lymphocyte count in both groups was higher than that before treatment (P <0.05), and the treatment group was significantly higher than the control group at 72 weeks after treatment (P <0.05). CD45RO lymphocyte count and CD45RO lymphocyte count showed an upward trend with the prolongation of treatment period (P <0.05). At 72 weeks of treatment, CD45RA lymphocyte count increased more significantly in treatment group (P <0.05), while CD45RO lymphocyte count No significant difference between the two groups was statistically significant (P> 0.05). Conclusion Immune 2 particles can increase the number of CD4 + lymphocytes in patients with AIDS-induced HIV-re-immunization after HAART, thereby improving the body immunity.