使用异戊烯醇和双戊烯为原料经过酯化和缩合反应制取α-红没药醇,酯化反应最佳工艺条件为:35℃、异戊烯醇和甲酸摩尔比1∶1.5、反应6小时,得率92%。缩合阶段最佳工艺即溶剂量50%,催化剂用量7%,温度70℃,异戊烯醇甲酸酯与双戊烯摩尔比1∶4,得率68.0%。 Α-bisabolol was prepared by esterification and condensation reaction using isoprenol and dipentene as raw materials. The optimum conditions of esterification reaction were 35 ℃, the molar ratio of isopentenol to formic acid was 1: 1.5, reaction 6 Hour, yield 92%. The optimum process of condensation stage is 50% of solvent, 7% of catalyst, temperature 70 ℃, the molar ratio of isopentenyl formate to dipentene is 1: 4, and the yield is 68.0%.