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目的探讨血液灌流联合异甘草酸镁治疗急性百草枯中毒患者的临床疗效。方法选取2010年3月至2014年3月常州市第四人民医院收治的急性百草枯中毒患者86例为研究对象,按随机数字表法分为3组,A组18例采用常规治疗,B组27例采用血液灌流加常规治疗,C组41例采用血液灌流联合异甘草酸镁加常规治疗。比较各组患者存活率、多器官功能障碍综合征(MODS)发生率和肝肾功能损伤、中毒性心肌炎等的变化。结果 B组与C组患者的存活率高于A组,MODS发生率和肝肾功能损伤、中毒性心肌炎等的发生率均明显低于A组,差异均有统计学意义(P<0.05);B组与C组间各指标比较,差异无统计学意义(P>0.05)。结论血液灌流与异甘草酸镁联合治疗百草枯中毒能够有效减轻脏器的损伤程度,降低患者死亡率。
Objective To investigate the clinical efficacy of hemoperfusion combined with magnesium isoglycyrrhizinate in patients with acute paraquat poisoning. Methods A total of 86 acute paraquat poisoning patients admitted to the Fourth People’s Hospital of Changzhou City from March 2010 to March 2014 were selected as the study subjects. They were divided into 3 groups according to the random number table. 18 patients in group A received routine treatment and group B Twenty-seven patients were treated with hemoperfusion plus conventional therapy. Group C (n = 41) was treated with hemoperfusion combined with magnesium glycyrrhizinate plus conventional therapy. The survival rate, multiple organ dysfunction syndrome (MODS) incidence, hepatic and renal dysfunction and toxic myocarditis were compared between the two groups. Results The survival rates of patients in group B and group C were higher than those in group A, and the incidence of MODS, liver and renal dysfunction and toxic myocarditis were significantly lower than those in group A (P <0.05). There was no significant difference between B group and C group (P> 0.05). Conclusion Hemoperfusion combined with magnesium isoglycyrrhizinate in the treatment of paraquat poisoning can effectively reduce the degree of organ damage and reduce the mortality of patients.