肝纤维化的形成是由于肝脏控制基质形成与沉积和基质降解与清除之间平衡的丧失,从而引起结缔组织的过度沉积进而纤维化。肝纤维化是慢性肝病向肝硬化发展的前驱阶段和必经过程,如能早期发现并及时治疗,尚可逆转至正常,因此探索肝纤维化的早期诊断一直是肝病学领域研究的重要课? The formation of liver fibrosis is due to a loss of balance between liver control matrix formation and deposition and matrix degradation and clearance, causing excessive deposition of connective tissue and thus fibrosis. Liver fibrosis is a precursor and a necessary course of development of chronic liver disease to liver cirrhosis. If it can be detected early and treated promptly, liver fibrosis can still be reversed to normal. Therefore, to explore early diagnosis of liver fibrosis has been an important lesson in the field of hepatology.