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目的：制备法莫替丁缓释片剂，并评价其释放特性。方法：用正交试验设计对片剂的处方、工艺进行筛选与优化，制备法莫替丁缓释片剂，测定其释放特性。结果：以优选的处方、工艺所制备的片剂，体外释药性能良好，符合Ｈｉｇｕｃｈｉ模型，持续释药达１２ｈ以上。结论：该片剂处方合理，工艺简单，适合于工业化生产，可为消化性溃疡病的临床防治提供一个新剂型。
OBJECTIVE: To prepare famotidine sustained release tablets and evaluate its release characteristics. Methods: Orthogonal design was used to optimize the formulation and process of tablets. The sustained-release tablets of famotidine were prepared and their release characteristics were determined. Results: The tablets prepared by the best prescription and technique had good in vitro release performance and met the Higuchi model with sustained release for more than 12h. Conclusion: The tablet prescription is reasonable, the process is simple, suitable for industrial production, for the clinical prevention and treatment of peptic ulcer disease provides a new dosage form.