目的探讨重症手足口病的发病特点,临床表现,检验结果分析及治疗经验体会。方法对50例重症手足口病患儿的发病季节、发病年龄、临床表现、检验结果、治疗效果等进行分析。结果重症手足口病患儿大部分为EV71病毒感染,以小于3岁儿童常见,常见临床症状为发热及神经系统受累为主,常有白细胞、血糖、CK-MB增高,大剂量丙种球蛋白的治疗有显著疗效。结论重症手足口病主要表现为神经系统受累以及多器官功能影响为主,早期识别及早期干预是治疗的关键。 Objective To explore the incidence of severe hand-foot-mouth disease, clinical manifestations, test results and experience in treatment experience. Methods The onset season, age of onset, clinical manifestations, test results and treatment effect of 50 cases of HFMD were analyzed. Results The majority of children with severe hand-foot-mouth disease were infected with EV71 virus, common in children younger than 3 years old. Common clinical symptoms were fever and nervous system involvement, and leucocyte, blood glucose and CK-MB were often increased. High-dose gamma globulin Treatment has a significant effect. Conclusion The main manifestations of severe HFMD are mainly nervous system involvement and multiple organ function. Early identification and early intervention are the key points of treatment.