1995年 8月～ 1998年 7月对 85例恶性胸腹腔积液患者 (其中恶性胸腔积液 47例 ,恶性腹水 38例 )应用DDP胸腹腔内注射进行疗效观察。在尽量抽尽胸腔积液及腹水后 ,以适量生理盐水溶解DDP 80～ 10 0mg m2 经导管注入胸腹腔 ,每 3周 1次 ,连用 2次。对恶性胸腔积液的有效率为 6 8.1% ( 32 47) ,对恶性腹水的有效率为 6 3 .2 % ( 2 4 38) ,主要不良反应为胃肠道反应 ,无明显骨髓抑制及肝肾功能损害 From August 1995 to July 1998, 85 patients with malignant pleural effusion and effusion (including 47 cases of malignant pleural effusion and 38 cases of malignant ascites) were treated with intra-abdominal injection of DDP. After aspiration of pleural effusion and ascites as possible, with an appropriate amount of saline dissolved DDP 80 ~ 10mg m2 via catheter into the abdominal cavity, once every 3 weeks, once every 2 times. The effective rate of malignant pleural effusion was 6 8.1% (32 47), and the effective rate of malignant ascites was 62.2% (2 4 38). The main adverse reactions were gastrointestinal reactions, no obvious myelosuppression and liver Kidney damage