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宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)由于被证实与宫颈癌密切相关,且发生率较高,已受到妇科肿瘤大夫的重视。阴道上皮内瘤变(vaginal intraepithelial neoplasia,VAIN)是一种罕见的阴道上皮组织学病变,由于发生率低且病变不易被常规检查发现,很容易被妇科肿瘤大夫忽视。目前研究表明VAIN发病的最主要危险因素为同期患CIN,因此建议CIN患者常规进行阴道检查判断是否合并VAIN。由于VAIN与CIN发展并不一致,VAIN进展为浸润癌概率更大,故当两者并存时,应以最重病变为重点,并根据具体病变级别的不同进行治疗方案调整。
Cervical intraepithelial neoplasia (CIN) has been taken seriously by gynecologic oncologists due to their close association with cervical cancer and high incidence. Vaginal intraepithelial neoplasia (VAIN) is a rare vaginal epithelial histological lesion that is easily overlooked by gynecologic oncologists because of its low incidence and its difficulty in routine examination. The current study shows that the most important risk factor for the onset of VAIN is CIN in the same period. Therefore, it is suggested that vaginal examination be performed routinely in CIN patients to determine whether VAIN is combined. Because VAIN is not consistent with CIN development, VAIN is more likely to progress to invasive cancer. Therefore, when both of them coexist, the most serious disease should be emphasized, and the treatment plan should be adjusted according to the specific grade of lesion.