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目的 研究拉莫三嗪联合丙戊酸钠治疗对癫痫患儿疗效改善不良事件及预后的影响?方法 挑选本院收治的122例癫痫患儿，按数字表法分为两组，每组61例?对照组实施丙戊酸钠治疗，试验组实施拉莫三嗪联合丙戊酸钠治疗，分析比较两组患儿不良事件的发生情况，以及治疗前后疗效的改善情况和预后情况?结果 对比两组治疗前癫痫发作的次数，无差异(P>0.05);与治疗前比，治疗3个月及半年后两组癫痫发作的次数均明显下降，且试验组少于对照组(P0.05). Compared with the pre-treatment， the average levels of TC and TG in the two groups after three months and six months of treatment increased significantly， and the experimental group was higher than the control group (P <0.05). Conclusion Lamotriazine combined with valproate can effectively reduce the incidence of seizures and adverse events in children with epilepsy. It can also significantly improve the levels of TC and TG in children， and improve the efficacy and prognosis. It is worth clinical promotion.