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目的评价血清降钙素原(PCT)在全身炎症反应综合征(SIRS)病原学诊断及病情严重程度判断中的价值。方法选择2008年11月至2009年11月我院儿科收治的SIRS的患儿66例,根据病原学检测结果分为细菌性感染组(43例)和非细菌感染组(23例)。比较两组间PCT、超敏C-反应蛋白(hs-CRP)、白细胞(WBC)计数、中性粒细胞的差别及PCT与危重评分的相关性。结果细菌性感染组的PCT值明显高于非细菌感染组(P<0.05),但两组hs-CRP、WBC计数、中性粒细胞水平比较差异无统计学意义(P>0.05)。血清PCT水平与小儿危重病例评分呈负相关(r=-0.812,P<0.05)。结论脓毒血症患者PCT对病原学诊断方面,血清PCT的价值优于hs-CRP、WBC计数、中性粒细胞比例,是敏感的血清学标志;PCT水平和细菌感染所致的SIRS患儿的严重程度相关。
Objective To evaluate the value of serum procalcitonin (PCT) in the etiological diagnosis and severity of systemic inflammatory response syndrome (SIRS). Methods Sixty-six children with SIRS admitted to our hospital from November 2008 to November 2009 were divided into bacterial infection group (n = 43) and non-bacterial infection group (n = 23) according to the results of pathogen detection. The PCT, hs-CRP, WBC count, neutrophil difference and correlation between PCT and the risk score were compared between the two groups. Results The PCT value of bacterial infection group was significantly higher than that of non-bacterial infection group (P <0.05). However, there was no significant difference in hs-CRP, WBC count and neutrophil count between the two groups (P> 0.05). The level of serum PCT was negatively correlated with the score of critically ill children (r = -0.812, P <0.05). Conclusions The value of serum PCT in patients with sepsis is better than that of hs-CRP, WBC count and neutrophil ratio in the diagnosis of PCT. It is a sensitive serological marker for PCT in sepsis patients. PCT levels and bacterial infections in children with SIRS The severity of the correlation.