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目的:观察山东地区类风湿关节炎(RA)发病及其临床表现与人类白细胞相关抗原(HLA)-DR1,DR4、DR10等位基因频率的关系。方法:特异性引物聚合酶链式反应(PCR-SSP)方法分别测定132例RA患者及130例正常人的HLA-DR1,DR4、DR10的基因频率。结果:3种基因在132例RA患者中基因频率分别为9.8%、46.2%、11.4%,而在正常对照组的相应基因频率分别为5.4%、19.2%、6.9%,其中HLA-DR4较正常对照有统计学意义,HLA-DR1,DR10则无统计学意义。结论:山东地区RA易感性与共同表位(SE)有关,其中主要和HLA-DR4关联密切。HLA-DR1,DR10不是RA易感基因。
Objective: To observe the relationship between the incidence and clinical manifestations of rheumatoid arthritis (RA) and HLA-DR1, DR4 and DR10 alleles in Shandong Province. Methods: The gene frequencies of HLA-DR1, DR4 and DR10 in 132 RA patients and 130 healthy controls were detected by polymerase chain reaction (PCR-SSP). Results: The frequencies of the three genes in the 132 RA patients were 9.8%, 46.2% and 11.4%, respectively. The frequencies of the corresponding genes in the normal control group were 5.4%, 19.2% and 6.9% Control was statistically significant, HLA-DR1, DR10 was not statistically significant. Conclusion: The susceptibility to RA in Shandong is related to the common epitope (SE), which is mainly associated with HLA-DR4. HLA-DR1 and DR10 are not RA-susceptible genes.