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目的 :观察大剂量静脉注射免疫球蛋白 (IVIG)治疗难治性肾病综合征伴低 Ig G血症的疗效。方法 :对 3 4例难治性肾病伴低 Ig G血症的患儿在常规剂量的强的松、环磷酰胺治疗的基础上加用 IVIG治疗 ,观察其尿蛋白阴转率、血浆白蛋白、胆固醇三项指标 ,并随访 1.5～ 4.5年。另设 3 0例患儿作为对照组。结果 :治疗组尿蛋白阴转率、血浆白蛋白、胆固醇三项指标恢复明显优于对照组 (P<0 .0 1) ;院内感染率明显低于对照组 (P<0 .0 1)。完全缓解率治疗组为 85 .2 9% ,对照组 5 6.67% ,两组对比差异有显著性 (P<0 .0 1)。结论 :联合强的的松及环磷酰胺治疗难治性肾病综合征伴低 Ig G血症安全 ,有效
Objective: To observe the curative effect of high dose intravenous immunoglobulin (IVIG) in the treatment of refractory nephrotic syndrome with low IgA. Methods: 34 children with refractory nephropathy and low IgA hyperlipidemia were treated with intravenous injection of prednisone and cyclophosphamide at the dose of IVIG. The urinary protein turnover rate, plasma albumin , Three indicators of cholesterol, and follow-up 1.5 ~ 4.5 years. Another 30 cases of children as a control group. Results: The urinary protein conversion rate, plasma albumin and cholesterol in the treatment group were significantly better than those in the control group (P <0.01). The nosocomial infection rate was significantly lower in the treatment group than in the control group (P <0.01). The complete response rate was 85.29% in the treatment group and 5 6.67% in the control group, with significant difference between the two groups (P <0.01). Conclusions: Combination of prednisone and cyclophosphamide for the treatment of refractory nephrotic syndrome with hypov IgA is safe and effective