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目的:观察早期微量喂养对早产极低出生体重儿的临床效果。方法:将60例早产极低出生体重儿随机分为观察组(n=30)和对照组(n=30),观察组自生后2～3天开始微量喂养并静脉营养,对照组采用静脉营养至病情较稳定后再开始喂养,胃肠喂养开始时间最早为生后5天。观察两组患儿的体重变化、达到完全胃肠喂养所需要的时间、住院时间、是否有坏死性小肠结肠炎等,并监测血清胆红素、血脂、肝、肾功能等改变。结果:观察组达到完全胃肠喂养需要的时间和住院时间明显缩短、静脉营养时间缩短、喂养不耐受发生率均显著低于对照组(P均<0.05),但两组坏死性小肠结肠炎的发生率无显著性差异(P>0.05)。结论:早期微量喂养能提高早产极低出生体重儿对喂养的耐受性,改善胃肠道动力,尽早适应胃肠喂养,有利于疾病的康复,且不增加坏死性小肠结肠炎的患病率。
Objective: To observe the clinical effect of early micronutrient feeding on preterm low birth weight infants. Methods: Sixty preterm, very low birth weight infants were randomly divided into observation group (n = 30) and control group (n = 30). The observation group began to be fed micronutrient and vein nutrition 2-3 days after birth, while the control group received intravenous nutrition To the condition is stable before feeding, gastrointestinal feeding start time as early as 5 days after birth. Observe the change of body weight of the two groups of children to achieve the time required for complete gastrointestinal feeding, length of stay, whether there is necrotizing enterocolitis, and monitoring of serum bilirubin, blood lipids, liver and kidney function changes. Results: The time required for complete gastrointestinal feeding in the observation group was significantly shorter than that in the control group (P <0.05), and the length of hospital stay was shorter, and the incidence of feeding intolerance was shorter than that of the control group (P <0.05). However, necrotizing enterocolitis The incidence was no significant difference (P> 0.05). CONCLUSION: Early micronutrient feeding can increase the tolerance of feeding preterm low birth weight infants, improve gastrointestinal motility, adapt to gastrointestinal feeding as soon as possible, which is beneficial to the recovery of the disease without increasing the prevalence of necrotizing enterocolitis .