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目的:总结儿童及青少年嗅神经母细胞瘤(ENB)的诊断和治疗特点。方法:回顾性分析我院1993～2004年经治的4例儿童及青少年ENB的临床资料,并进行文献复习。结果:儿童及青少年ENB以11～15岁发病率最高,主要症状为鼻塞、眼球突出、鼻出血及头痛等;肿瘤主要侵犯鼻腔、筛窦、眼眶和前颅窝。治疗方式主要为手术加放疗,其次为单纯手术。患儿主要因原发病死亡。结论:儿童及青少年ENB少见,其恶性程度高,宜采取综合治疗,预后不良。
Objective: To summarize the diagnostic and therapeutic characteristics of children with adolescent olfactory neuroblastoma (ENB). Methods: The clinical data of 4 children and adolescents admitted to our hospital from 1993 to 2004 were retrospectively reviewed and reviewed. Results: The incidence of ENB in children and adolescents was the highest at 11 ~ 15 years old. The main symptoms were nasal congestion, prominent eyes, nosebleeds and headache. The tumors mainly infiltrated the nasal cavity, ethmoid sinus, orbit and anterior fossa. The main treatment for surgery plus radiotherapy, followed by simple surgery. Children mainly due to primary disease died. Conclusion: Children and adolescents with rare ENB, its high degree of malignancy, should take comprehensive treatment, the prognosis is poor.