目的了解不同孕期孕妇血清同型半胱氨酸(Hcy)及叶酸(FA)水平。方法 2012年2月-2014年12月选择98例妊娠女性为观察组,100例未孕女性为对照组。检测并比较两组女性血清Hcy及FA水平。结果孕早期、孕中期、孕晚期、产后女性与对照组女性血清Hcy水平分别比较,差异均有统计学意义(P<0.05)。孕晚期、产后女性与孕早期女性血清Hcy水平分别比较,差异均有统计学意义(P<0.05)。孕早期、孕中期女性与对照组女性血清FA水平分别比较,差异均有统计学意义(P<0.05)。孕中期、孕晚期、产后女性与孕早期女性血清FA水平分别比较,差异均有统计学意义(P<0.05)。产后女性与孕中期、孕晚期女性血清FA水平分别比较,差异均有统计学意义(P<0.05)。结论正常孕妇孕期血清Hcy水平高于正常育龄期未孕女性,且在不同孕期呈逐渐降低趋势。 Objective To understand the levels of serum homocysteine ​​(Hcy) and folic acid (FA) in different pregnant women. Methods From February 2012 to December 2014, 98 pregnant women were selected as observation group and 100 non-pregnant women as control group. The levels of serum Hcy and FA in the two groups were detected and compared. Results The levels of Hcy in pregnant women, pregnant women, pregnant women and pregnant women were significantly higher than those in the control group (P <0.05). Third trimester of pregnancy, postpartum women and pregnant women serum Hcy levels were compared, the differences were statistically significant (P <0.05). The levels of serum FA in pregnant women, pregnant women and controls were significantly lower than those in pregnant women (P <0.05). The levels of serum FA in postpartum women and pregnant women in the third trimester and third trimester were significantly different (P <0.05). The difference of serum FA levels between postpartum women and the third trimester and third trimester women was statistically significant (P <0.05). Conclusions The serum Hcy level of pregnant women during pregnancy is higher than that of normal pregnant women, and gradually decreases at different stages of pregnancy.