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对148例正常个体进行2年随访,其中14例进展为IGT,110例仍NGT,12例为IFG,8例进展为DM,4例进展为IGT+IFG,总共124例作为研究对象。结果:(1)与NGT组比,IGT组OGTT 30min血糖、EINS及HOMA-IR明显升高(P<0.05),而半小时胰岛素、早期胰岛素分泌指数(P<0.05)、胰岛素敏感指数降低(P<0.05)。(2)与IGT基线资料相比,BMI、OGTT 2小时血糖、半小时血糖、空腹胰岛素(FINS)及HOMA-IR升高(P<0.05),而半小时胰岛素、早期胰岛素分泌指数(P<0.05)、胰岛素敏感性指数降低(P<0.05)。结论:从NGT向IGT进展过程中,存在胰岛素抵抗程度增加和早期胰岛素分泌功能减退。
148 normal subjects were followed up for 2 years. Of them, 14 were IGT, 110 were still NGT, 12 were IFG, 8 were DM, and 4 were IGT + IFG. A total of 124 patients were included in the study. Results: (1) Compared with NGT group, the levels of blood glucose, EINS and HOMA-IR of OGTT in IGT group were significantly increased at 30 min (P <0.05), while the insulin secretion index at early hour P <0.05). (2) Compared with the IGT baseline data, BMI and OGTT increased 2-hour blood glucose, half-hour blood glucose, fasting insulin (FINS) and HOMA-IR, while half hour insulin and early insulin secretion index (P < 0.05), insulin sensitivity index decreased (P <0.05). CONCLUSIONS: During the progression from NGT to IGT, there is an increased level of insulin resistance and an impaired early insulin secretion.