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本实验观察了侧脑室注射γ-氨基丁酸及其拮抗剂印防己毒对背侧海马伤害性相关神经元诱发放电的影响。实验结果如下:<1>侧脑室注射γ-氨基丁酸可使多数背海马伤害性兴奋神经元的增频反应明显减弱(P<0.01);与此同时,多数背海马伤害性抑制神经元的减频反应亦明显减弱(P<0.01)。侧脑室注射γ-氨基丁酸对伤害性无关神经元有不同程度的激活作用。<2>侧脑室注射印防己毒对背海马伤害兴奋神经元及伤害性抑制神经元的伤害性反应,有呈现对抗性反应的,有加强的,还有无改变的。<3>侧脑室注射印防己毒可以使外源性γ-氨基丁酸对多数伤害性兴奋神经元的抑制作用明显减弱(P<0.01)。 上述结果提示:伤害性刺激时背海马伤害性相关神经元的诱发反应形式与脑内γ-氨基丁酸水平密切相关。
In this study, we observed the effects of intracerebroventricular injection of γ-aminobutyric acid and its antagonist Aristolochia sinica on induced discharge of nociceptive neurons in dorsal hippocampus. The experimental results are as follows: <1> Intracerebroventricular injection of γ-aminobutyric acid significantly attenuated the frequency-response of most nociceptive nociceptive neurons in the dorsal hippocampus (P <0.01); meanwhile, most nociceptive nociceptive neurons The frequency response was also significantly reduced (P <0.01). Intracerebroventricular injection of γ-aminobutyric acid has a different degree of activation of non-nociceptive neurons. <2> Intracerebroventricular injection of anti-venom poisoning on the dorsal hippocampus injured neurons and nociceptive neurons nociceptive response, showing antagonistic response, there is no change. <3> Intracerebroventricular injection of anti-venom poisoning can make exogenous γ-aminobutyric acid inhibit the majority of nociceptive excitatory neurons significantly reduced (P <0.01). The above results suggest that the form of response induced by nociceptive nociception in hippocampal nociceptive neurons is closely related to the level of γ-aminobutyric acid in the brain.