曾报道红霉素是一种胃和小肠运动原活动的刺激物。这一大环内酯类抗生素可与近端小肠和结肠的运动性受体结合,协调循环运动原活动。红霉素可加速正常人的结肠转运和增加排便频率。虽然急性脊柱损伤后的反射性肠梗阻,并不认为是假结肠梗阻的一部分,但二者可能均因控制结肠活动的正常肠外机制干扰所致。作者用红霉素成功治疗了两例,1例反射性肠梗阻,另一例假结肠梗阻。 Erythromycin has been reported as a gastric and intestinal motility stimulus. This macrolide antibiotic binds to the proximal small intestine and colon motility receptors and coordinates circulating motility. Erythromycin can accelerate normal colon transit and increase the frequency of defecation. Although reflective ileus following acute spinal injury is not considered to be part of the false bowel obstruction, both may be due to normal parenteral mechanisms that control colonic activity. The authors successfully treated with erythromycin in two cases, one case of reflective intestinal obstruction, another case of false colon obstruction.