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目的观察非洛地平缓释片治疗高血压病的临床疗效和安全性。方法 88例高血压病患者随机分为治疗组和对照组各44例。治疗组给予非洛地平缓释片;对照组给予盐酸贝那普利片,观察两组临床疗效和治疗前后收缩压(SBP)、舒张压(DBP)变化情况和不良反应。结果两组治疗后SBP、DBP均明显低于治疗前(P<0.05);组间治疗后比较,差异无统计学意义(P>0.05),治疗组降压幅度优于对照组;治疗组总有效率为90.91%。对照组总有效率为84.09%,差异无统计学意义(P>0.05);两组不良反应比较,差异有统计学意义(P<0.05)。结论非洛地平缓释片治疗高血压效果确切,不良反应少,适合高血压患者长期服用。
Objective To observe the clinical efficacy and safety of felodipine sustained release tablets in the treatment of hypertension. Methods 88 patients with hypertension were randomly divided into treatment group and control group, 44 cases each. The treatment group was given felodipine sustained-release tablets. The control group was given benazepril hydrochloride tablets. The clinical efficacy and the changes of SBP and DBP before and after treatment were observed and the adverse reactions were observed. Results The SBP and DBP in both groups were significantly lower than those before treatment (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05) The effective rate is 90.91%. The total effective rate of the control group was 84.09%, the difference was not statistically significant (P> 0.05). There was significant difference between the two groups in adverse reactions (P <0.05). Conclusion Felodipine extended release tablets for the treatment of hypertension with exact adverse reactions, suitable for long-term use of patients with hypertension.