目的对比盐酸伐昔洛韦与阿昔洛韦治疗儿童水痘的临床效果。方法选取2012-06-01—2012-12-01我院收治的水痘患儿140例,将其随机分成治疗组和对照组,各70例。治疗组口服盐酸伐昔洛韦分散片,对照组口服阿昔洛韦片。比较两组疗效,并观察两组不良反应发生情况。结果治疗组总有效率为98.6%,高于对照组的95.7%(P<0.05)。治疗组2例患儿出现白细胞计数降低,对照组3例患儿出现白细胞计数降低,其余均未出现严重不良反应。结论盐酸伐昔洛韦分散片治疗儿童水痘的临床效果优于阿昔洛韦,且安全,值得临床推广。 Objective To compare the clinical effects of valacyclovir hydrochloride and acyclovir in the treatment of chickenpox in children. Methods Forty-six children with chickenpox admitted to our hospital from June 2012 to January 2012 were randomized into treatment group (n = 70) and control group (n = 70). The treatment group oral valacyclovir hydrochloride tablets, the control group oral acyclovir tablets. The curative effect of two groups was compared, and the incidence of adverse reactions in both groups was observed. Results The total effective rate was 98.6% in the treatment group, which was 95.7% higher than that in the control group (P <0.05). Two patients in the treatment group had a decrease in white blood cell count, three patients in the control group had a decrease in white blood cell count, and the rest had no serious adverse reactions. Conclusion Valacyclovir hydrochloride dispersible tablets in the treatment of children with chicken pox clinical effect is better than acyclovir, and safe, worthy of clinical promotion.