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目的使用尿微白蛋白试条检测98例糖尿病患者及26例体检健康者的尿微白蛋白浓度,旨在早期发现糖尿病肾病(DN),探讨病程、血糖控制水平对DN的影响。方法使用德国宝灵曼公司生产的尿微白蛋白试条(Micral-TestⅡ)进行尿微白蛋白浓度测定,同时测定空腹血糖。结果98例糖尿病患者按病程<5年、5～10年、>10年分组,各组间尿白蛋白异常率分别为11.7%、33.3%、55.0%(P<0.01);按空腹血糖<7.0mmol/L、7.0～10.0mmol/L、>10.0mmol/L分组,各组间尿白蛋白异常率分别为9.7%、21.6%、43.3%(P<0.01)。结论DN的发生、发展与病程、血糖控制水平呈显著性正相关。尿微白蛋白是早期发现DN的敏感指标。
Objective To detect urine microalbuminuria in 98 diabetics and 26 healthy subjects by using urine microalbumin strips. The aim is to detect diabetic nephropathy (DN) in early stage and investigate the effect of disease duration and blood glucose control on DN. Methods Urinary microalbumin concentration was measured by using Micral-Test Ⅱ manufactured by Böhrenmann GmbH, Germany. Fasting plasma glucose was measured at the same time. Results 98 patients with diabetes were grouped according to their duration of disease (5 years, 5 to 10 years and 10 years). The abnormal rates of urinary albumin were 11.7%, 33.3% and 55.0% respectively (P <0.01) mmol / L, 7.0 ~ 10.0mmol / L and> 10.0mmol / L. The abnormal rates of urinary albumin were 9.7%, 21.6% and 43.3% in each group (P <0.01). Conclusion The occurrence and development of DN have a significant positive correlation with the duration of disease and the level of blood sugar control. Urine microalbumin is a sensitive indicator of early detection of DN.