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催乳素(PRL)可在垂体和垂体外生成和分布,除了具有激素的一般特性外,还具有细胞因子的一些特点。PRL受体属造血生长因子受体家族,通过Janus激酶-信号转导与转录激活因子(JAK-STAT)途径激活信号转导通路发挥其生物作用。研究表明PRL在许多肿瘤中的表达明显增高,其可通过抑制细胞凋亡,缩短细胞周期而促进细胞分裂,对肿瘤的生长有促进作用。本文阐述了催乳素与乳腺癌、前列腺癌及子宫肌瘤的关系。
Prolactin (PRL) can be generated and distributed in the pituitary and pituitary, in addition to the general characteristics of the hormone, but also has some of the characteristics of cytokines. The PRL receptor is a hematopoietic growth factor receptor family that exerts its biological effects by activating the signal transduction pathway through Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Studies have shown that PRL expression was significantly increased in many tumors, which can promote cell division and promote tumor growth by inhibiting apoptosis and shortening the cell cycle. This article describes the relationship between prolactin and breast, prostate and uterine fibroids.