论文部分内容阅读
目的进行大剂量的三苯氧胺(TAM)160 mg联合化疗对雌激素受体(ER)阳性的非小细胞肺癌患者的近期疗效分析和毒副作用的观察。方法ER阳性和阴性的非小细胞肺癌患者各30例,分为TAM+化疗组及化疗组,进行2个周期以上的治疗后评价疗效。结果TAM+化疗组有效率(53%)较化疗组(31%)高。免疫功能改善更显著。不良反应主要是恶心、呕吐、白细胞(UBC)减少和周围神经毒性,经对症止吐、升白细胞等处理后均恢复正常。结论采用大剂量TAM治疗能提高ER阳性非小细胞肺癌的临床疗效而且安全、经济,值得进一步研究。
Objective To evaluate the short-term efficacy and side effects of high-dose Tamoxifen (TAM) 160 mg combined with chemotherapy on patients with estrogen receptor (ER) -positive non-small cell lung cancer. Methods Thirty patients with ER positive and negative NSCLC were divided into TAM + chemotherapy group and chemotherapy group. The therapeutic effect was evaluated after more than two cycles. Results The effective rate of TAM + chemotherapy group (53%) was higher than that of chemotherapy group (31%). Immune function improved more significantly. Adverse reactions are mainly nausea, vomiting, decreased white blood cell (UBC) and peripheral neurotoxicity, after symptomatic antiemetic, leukocyte and other treatment were returned to normal. Conclusion The high dose of TAM treatment can improve the clinical efficacy of ER-positive non-small cell lung cancer and it is safe and economical, which deserves further study.