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目的:比较国产和进口厄贝沙坦片对原发性高血压的疗效和经济学分析,为临床经济合理用药提供参考。方法:选择原发性高血压患者120例,随机分为对照组和观察组各60例。对照组患者给予国产厄贝沙坦片治疗,观察组患者给予进口厄贝沙坦片治疗,连续治疗8周。观察其临床疗效的差异,并采用药物经济学原理进行成本-效果分析。结果:对照组总有效率为82.25%,成本-效果比为2.47。观察组总有效率为91.93%,成本-效果比为3.25。两组比较,差异有统计学意义(P<0.05)。以对照组作为参照,增量成本-效果比为9.89。结论:经过成本-效果综合分析,采用国产厄贝沙坦片治疗原发性高血压优于进口厄贝沙坦片。
Objective: To compare the curative effect and economic analysis of domestic and imported irbesartan tablets on essential hypertension, and to provide a reference for clinical economical and rational drug use. Methods: 120 patients with essential hypertension were randomly divided into control group and observation group of 60 cases. Control group patients given domestic irbesartan tablets treatment, observation group patients were treated with imported irbesartan tablets, continuous treatment for 8 weeks. To observe the difference of clinical efficacy, and to use cost-effectiveness analysis based on the principles of pharmacoeconomics. Results: The control group had a total effective rate of 82.25% and cost-effectiveness ratio of 2.47. The observation group had a total effective rate of 91.93% and cost-effectiveness ratio of 3.25. The difference between the two groups was statistically significant (P <0.05). Taking the control group as reference, the incremental cost-effectiveness ratio was 9.89. Conclusion: After the cost - effect comprehensive analysis, the use of domestic irbesartan tablets is superior to the imported irbesartan tablets in the treatment of essential hypertension.