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目的研制防治产后乳汁分泌不足的中药复方制剂。方法采用当归、黑芝麻、党参等中药,经水提醇沉工艺制备成养血生乳口服液,应用显色反应、薄层确认和高效液相色谱法控制其内在质量,并对80例正常产妇进行了临床观察。结果阿魏酸的进样量在0.1～0.5μg范围内与峰面积积分值呈良好线性关系,平均加样回收率为98.6%(RSD=1.04%,n=6);正常产妇产后服用该制剂能促进产后迅速升乳,显著提高其日泌乳量,预防产后乳汁分泌不足的发生。结论养血生乳口服液的质量稳定,是防治产妇分娩后乳汁分泌不足的理想制剂。
Objective To develop and prevent the secretion of postpartum milk deficiency of traditional Chinese medicine compound preparation. Methods Chinese angelica, black sesame, Codonopsis and other Chinese herbs were prepared into nourishing raw milk oral solution by water extraction and alcohol precipitation. The internal quality was controlled by color reaction, TLC and HPLC. Eighty normal pregnant women Clinical observations were made. Results The sample volume of ferulic acid showed a good linear relationship with the peak area integral value in the range of 0.1-0.5 μg with an average recovery of 98.6% (RSD = 1.04%, n = 6). The normal maternal postpartum Can promote rapid lactation after delivery, significantly increase the amount of milk on the day to prevent the occurrence of postpartum milk secretion. Conclusion Nourishing raw milk oral liquid quality is stable, is the ideal preparation for prevention and treatment of maternal milk secretion after delivery.