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目的探讨Rad51和Chk1在散发性大肠腺瘤癌变中的表达及意义。方法采用免疫组化法检测71例大肠黏膜、66例散发性大肠腺瘤伴上皮不典型增生和98例大肠腺瘤癌变中,Rad51和Chk1的表达,并分析其与大肠癌临床病理特征的关系。结果①在大肠黏膜组、腺瘤组和癌变组中,Rad51和Chk1的表达水平逐渐升高。②在腺瘤癌变组中,Rad51的表达与肿瘤的分化程度、淋巴结转移有关(P<0.05),Chk1的表达与肿瘤的分化程度有关。③在腺瘤组中,中重度不典型增生者Rad51和Chk1的阳性表达高于轻度不典型增生者。结论 Chk1和Rad51在大肠腺瘤癌变的发生、发展过程中起重要作用。
Objective To investigate the expression and significance of Rad51 and Chk1 in the carcinogenesis of sporadic colorectal adenoma. Methods The expressions of Rad51 and Chk1 in 71 cases of colorectal mucosa, 66 cases of sporadic colorectal adenoma with epithelial atypical hyperplasia and 98 cases of colorectal adenocarcinoma were detected by immunohistochemistry. The relationship between them and the clinicopathological features of colorectal cancer . Results ① The expression of Rad51 and Chk1 gradually increased in the colorectal mucosa, adenoma and carcinogenesis group. ② In the adenoma carcinogenesis group, the expression of Rad51 was related to the differentiation degree of tumor and lymph node metastasis (P <0.05), and the expression of Chk1 was related to the degree of tumor differentiation. ③ In the adenoma group, the positive expression of Rad51 and Chk1 in moderate-severe atypical hyperplasia was higher than that in mild dysplasia. Conclusion Chk1 and Rad51 play an important role in the carcinogenesis and progression of colorectal adenoma.