目的观察非穿透性小梁手术(NPTS)联合丝裂霉素C(MMC)及羊膜移植治疗开角型青光眼的临床疗效。方法选择19例双眼视力、眼压、视野相近的开角型青光眼病例,采用自身对照,1只眼行小梁切除术,另1只眼行非穿透性小梁切除术。术后观察视力、眼压、滤过泡、前房和房水情况,评估疗效。结果两种术式术后降眼压效果差异无统计学意义。非穿透性小梁切除术的术后并发症要比小梁切除术少。结论非穿透性小梁切除术是治疗开角型青光眼的有效方法 ,且术后并发症少。 Objective To observe the clinical effects of non-penetrating trabecular meshwork (NPTS) combined with mitomycin C (MMC) and amniotic membrane transplantation for open-angle glaucoma. Methods Nineteen cases of open-angle glaucoma with binocular visual acuity, intraocular pressure and similar field of vision were selected. One case was treated with trabecular surgery and one case with non-penetrating trabeculotomy. Postoperative visual acuity, intraocular pressure, filtration bleb, anterior chamber and aqueous humor, evaluate the curative effect. Results There was no significant difference in the intraocular pressure reduction effect between the two surgical procedures. Non-penetrating trabeculotomy postoperative complications less than trabeculectomy. Conclusion Non-penetrating trabeculectomy is an effective method for the treatment of open-angle glaucoma. There are few postoperative complications.