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已发现阳离子胰蛋白酶原(PRSS1)基因、囊性纤维化跨膜传导调节因子(CFTR)基因和胰分泌性胰蛋白酶抑制剂Kazall型(SPINK1)基因突变可显著提高个体对慢性胰腺炎(CP)的易感性。大量研究结果显示CTRC基因很可能为CP易感基因研究的新热点;TNF-238A基因、UGT1A7基因、CASR基因或乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)2及羧基酯脂肪酶(CEL)等与酒精代谢有关的基因等亦被认为有较好研究前景;GSTT-1*A和角蛋白8的作用尚难界定;而血色素沉着症基因(HFE)、二氧化锰超氧化剂物歧化酶(MnSOD)和谷胱甘肽转移酶同工酶(GSTP1)基因很可能与CP无关。但这仅仅是研究的开始,为彻底阐明CP易感基因之谜尚需付出巨大努力。
It has been found that mutations in the PRSS1 gene, CFTR gene and the pancreatic secretory trypsin inhibitor Kazall-type (SPINK1) gene have been found to significantly increase the individual’s susceptibility to chronic pancreatitis (CP) Susceptibility. A large number of studies have shown that CTRC gene is likely to be a new hotspot in the study of CP susceptibility genes; TNF-238A gene, UGT1A7 gene, CASR gene or alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) 2 and carboxylate fat (CEL) and other genes related to alcohol metabolism are also considered to have better research prospects; the role of GSTT-1 * A and keratin 8 is difficult to define; and hemochromatosis gene (HFE), manganese dioxide superoxide The MnSOD and GSTP1 genes are probably not related to CP. However, this is just the beginning of the research, and great efforts are needed to fully elucidate the mystery of CP susceptibility genes.