论文部分内容阅读
目的 :探讨阴茎癌淋巴结肿大与 ras癌基因 P 2 1蛋白的相关性。方法 :采用免疫组化 ABC法检测 110枚腹股沟淋巴结中 ras癌基因产物 P 2 1蛋白的表达状况 ,其中病理检查证实癌性和炎性肿大淋巴结各 40枚 ,正常淋巴结 80枚。结果 :P2 1蛋白在癌性、炎性和正常淋巴结中的阳性率分别为 92 .5 %、2 2 .5 %和 0 ;在炎性淋巴结中 ,P2 1蛋白阳性者平均 6个月和 17个月出现局部复发和骨盆转移。结论 :检测 P2 1蛋白表达状况 ,可提高癌前状态或癌前病变的诊断水平。
Objective: To investigate the correlation between the lymphadenopathy of penile cancer and the oncogene P 2 1 protein of ras. Methods: Immunohistochemical ABC method was used to detect the expression of ras oncogene product P 2 1 in 110 inguinal lymph nodes. The pathological examination confirmed 40 cancerous and inflammatory lymph nodes and 80 normal lymph nodes. Results: The positive rate of P2 1 protein in cancerous, inflammatory and normal lymph nodes was 92.5%, 25.5% and 0 respectively. In the inflammatory lymph nodes, the average positive rate of P2 1 protein was 6 months and 17 Month local recurrence and pelvic metastasis. Conclusion: The detection of P2 1 protein expression can improve the diagnosis of precancerous lesions or precancerous lesions.