论文部分内容阅读
目的观察TP方案与GP方案化疗晚期非小细胞肺癌(NSCLC)的疗效及毒副作用。方法回顾性分析我科2008年1月至2009年2月收治的70例晚期非小细胞肺癌(NSCLC)分成TP方案化疗组及GP方案化疗组患者,TP组35例,GP组35例,常规止吐对症处理,21 d为1个周期,接受至少2个周期化疗,治疗完成4周后评价疗效和不良反应。结果 70例均完成治疗,TP组总有效率40.0%;1年生存率为37.1%。GP组总有效率42.8%;1年生存率分别为生存率34.2%。两组有效率差异无统计学意义(P>0.05),两组1年生存率差异无统计学意义(P>0.05),化疗的毒副反应主要是消化道及血液学毒性,有差异,但皆可耐受。结论 TP方案与GP方案化疗晚期非小细胞肺癌(NSCLC),近期疗效和远期疗效相似,毒副作用有差异,须根据患者情况而选用不同的方案。
Objective To observe the curative effect and side effects of TP and GP chemotherapy in advanced non-small cell lung cancer (NSCLC). Methods Retrospective analysis of 70 patients with advanced non-small cell lung cancer (NSCLC) admitted to our department from January 2008 to February 2009 were divided into TP chemotherapy group and GP chemotherapy group, 35 cases in TP group and 35 cases in GP group, Antiemetic symptomatic treatment, 21 d for a period of at least 2 cycles of chemotherapy, treatment after 4 weeks to evaluate the efficacy and adverse reactions. Results All the 70 patients were treated. The total effective rate was 40.0% in TP group and 37.1% in 1-year. The total effective rate of GP group was 42.8%. The 1-year survival rates were 34.2% of the patients respectively. There was no significant difference between the two groups in the effective rate (P> 0.05). There was no significant difference in the one-year survival rate between the two groups (P> 0.05). The side effects of chemotherapy were mainly gastrointestinal and hematological toxicities, but there were differences Can be tolerated. Conclusion Both TP and GP regimens have similar short-term and long-term effects on chemotherapy of advanced non-small cell lung cancer (NSCLC), with different toxicities and side effects. Different regimens should be chosen according to the patient’s condition.