卵巢过度刺激综合征(OHSS)是促排卵过程中严重的医源性并发症,人绒毛膜促性腺激素诱导排卵使过多卵泡受刺激有关。其发病机制不明,病理生理特征主要为毛细血管通透性增加以及富含蛋白的液体停留在血管外间隙,导致血液浓缩,第三间隙水肿。现从血管内皮生长因子、血小板活化因子、溶血磷脂酸诱导炎性因子、囊性纤维化跨膜传导调节因子、肾素-血管紧张素系统对OHSS发病机制进行探讨分析,为临床更好地治疗和预防OHSS的发生提供理论依据。 Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complications of ovulation induction, and human chorionic gonadotropin-induced ovulation causes excessive follicles to be stimulated. Its pathogenesis is unclear, the main pathophysiological characteristics of capillary permeability and protein-rich liquid remain in the extravascular space, resulting in blood concentration, the third gap edema. Now from the vascular endothelial growth factor, platelet activating factor, lysophosphatidic acid-induced inflammatory cytokines, transmembrane conductance regulator of cystic fibrosis, renin-angiotensin system on the pathogenesis of OHSS to explore and analyze for better clinical treatment And to prevent the occurrence of OHSS provide a theoretical basis.