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目的研究BODE指数评估无创呼吸机治疗慢性阻塞性肺疾病急性加重期临床疗效的价值。方法选取攀枝花市第二人民医院2012年11月—2015年2月确诊并收治的慢性阻塞性肺疾病急性加重期患者168例,随机分为研究组和对照组,每组84例。对照组单纯应用内科常规治疗,研究组在对照组基础上加用无创呼吸机通气治疗。比较两组临床疗效、治疗前后的呼吸功能指标及BODE指数的变化情况。结果研究组总有效率为90.48%,高于对照组的70.24%(P<0.05)。治疗前两组血液酸碱度、动脉氧分压(Pa O2)、动脉二氧化碳分压(Pa CO2)、心率、呼吸频率、BODE指数比较,差异无统计学意义(P>0.05)。治疗后研究组血液酸碱度、Pa O2高于对照组,Pa CO2、心率、BODE指数低于对照组,差异有统计学意义(P<0.05),两组治疗后呼吸频率比较,差异无统计学意义(P>0.05)。两组均无不良反应发生。结论慢性阻塞性肺疾病急性加重期实施无创呼吸机临床疗效显著,且应用BODE指数对患者实施评估能够很好地反映出患者病情转归与综合体质状态。
Objective To study the value of BODE index in assessing the clinical efficacy of noninvasive ventilator in treating acute exacerbation of chronic obstructive pulmonary disease. Methods 168 patients with acute exacerbation of chronic obstructive pulmonary disease diagnosed and admitted in Panzhihua Second People’s Hospital from November 2012 to February 2015 were randomly divided into study group and control group with 84 cases in each group. The control group was treated with routine medical treatment only. The study group was treated with noninvasive ventilator ventilation on the basis of the control group. The clinical curative effect, respiratory function index and BODE index before and after treatment were compared between the two groups. Results The total effective rate was 90.48% in the study group, which was higher than 70.24% in the control group (P <0.05). The blood pH, Pa O2, PaCO2, heart rate, respiration rate and BODE index of the two groups before treatment had no significant difference (P> 0.05). PaO2 was higher in the study group than in the control group, Pa CO2, heart rate and BODE index were lower than those in the control group (P <0.05). There was no significant difference in respiratory rate between the two groups (P> 0.05). No adverse reactions occurred in both groups. Conclusion The clinical efficacy of non-invasive ventilator in acute exacerbation of chronic obstructive pulmonary disease is significant. Evaluating patients with BODE index can well reflect the patient’s condition and overall physique.