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高脂饮食会导致肥胖、高脂血症、胰岛素抵抗等代谢性疾病,其中高脂血症是诱发心血管疾病的重要危险因素,炎症因子(IL-6、IL-1β等)在疾病发展过程中起着重要的推动作用;近年来研究发现云芝多糖具有调节血脂,对抗动脉粥样硬化的作用,本实验采用高脂诱导雄性C57BL/6j高脂血症模型,同时给予云芝多糖干预,发现云芝多糖可以减少血浆中IFN-γ、IL-6、IL-1β的表达水平,同时上调血浆中IL-10和IL-13的表达水平,通过调节炎症因子的表达防止高脂饮食诱导的高甘油三酯血症的发生,达到预防高脂血症的作用.
High fat diet can cause obesity, hyperlipidemia, insulin resistance and other metabolic diseases, including hyperlipidemia is an important risk factor for cardiovascular disease, inflammatory factors (IL-6, IL-1β, etc.) in the disease development process In recent years, studies have found that polysaccharides can play a role in the regulation of blood lipids, against atherosclerosis. In this study, high fat-induced male C57BL / 6j hyperlipidemia model, given polysaccharide intervention, It was found that PSK could decrease the expression of IFN-γ, IL-6 and IL-1β in plasma and up-regulate the expression of IL-10 and IL-13 in plasma and prevent the hyperlipidemia-induced The incidence of hypertriglyceridemia, to prevent the role of hyperlipidemia.