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[目的]探讨复方嗜酸乳杆菌联合标准三联疗法根除幽门螺杆菌(Hp)的有效性及安全性。[方法]将165例经胃镜检查诊断为慢性胃炎伴黏膜萎缩或糜烂并经~(14)C-尿素呼气试验(~(14)C-UBT)证实Hp感染的患者随机分为试验组(81例)和对照组(84例)。对照组治疗采用标准三联疗法(口服埃索美拉唑20mg、bid+克拉霉素500mg、bid+阿莫西林1g、bid),试验组在对照组治疗的基础上加服复方嗜酸乳杆菌(1g、tid);2组疗程均为10d。治疗结束后4周复查所有患者~(14)C-UBT以评估Hp根除疗效。[结果]试验组、对照组实际完成方案者分别为75例、78例,试验组、对照组按意向治疗(ITT)分析Hp根除率分别为77.8%、61.9%,按方案(PP)分析Hp根除率分别为84.0%、66.7%,试验组ITT和PP根除率均显著高于对照组(P<0.05)。[结论]复方嗜酸乳杆菌联合标准三联疗法可提高Hp根除率,且安全性较高。
[Objective] To investigate the efficacy and safety of compound Lactobacillus acidophilus combined with standard triple therapy in the eradication of Helicobacter pylori (Hp). [Methods] A total of 165 patients diagnosed as chronic gastritis with atrophic mucosa atrophy or erosions by gastroscopy and confirmed by 14 C-urea breath test (~ (14) C-UBT) were randomly divided into experimental group 81 cases) and control group (84 cases). The control group was treated with standard triple therapy (oral esomeprazole 20mg, bid + clarithromycin 500mg, bid + amoxicillin 1g, bid). The experimental group was given compound Lactobacillus acidophilus (1g, tid); 2 groups of treatment are 10d. Four weeks after the end of treatment, all patients ~ (14) C-UBT were reviewed to evaluate the efficacy of Hp eradication. [Results] In the test group and the control group, the actual completion of the protocol was 75 cases and 78 cases. The ITT analysis showed that the Hp eradication rates were 77.8% and 61.9% in the experimental group and the control group, respectively, according to the protocol (PP) The eradication rates were 84.0% and 66.7% respectively. The ITT and PP eradication rates in the experimental group were significantly higher than those in the control group (P <0.05). [Conclusion] Compound Lactobacillus acidophilus combined with standard triple therapy can improve the eradication rate of Hp and is safe.