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目的观察和评价国产抗结核药物固定剂量复合制剂治疗老年初治菌阳肺结核的疗效及安全性。方法收集老年初治菌阳肺结核患者94例,以使用固定剂量复合剂的46例为治疗组,以使用散药异烟肼(H)、利福平(R)、吡嗪酰胺(Z)、乙胺丁醇(E)的48例为对照组。观察两组近期痰菌阴转、胸部X线病灶改变、不良反应等情况。结果第2个月末,治疗组和对照组痰涂片阴转率和培养阴转率分别为76.1%和71.7%、75.0%和72.9%,治疗满6个月时,治疗组和对照组痰涂片阴转率和培养阴转率分别为89.1%和91.3%、89.6%和89.6%。胸部X线明显改善(显吸及吸收),治疗组与对照组病灶吸收率分别为89.1%及89.6%。治疗组和对照组分别有4例(8.7%)、5例(10.4%)肝功能异常。结论固定剂量复合制剂与散药的治疗效果相同,不良反应相近,在老年肺结核患者治疗中值得推广应用。
Objective To observe and evaluate the efficacy and safety of the fixed-dose combination of Chinese-made anti-tuberculosis drugs in the treatment of newly diagnosed tuberculosis in elderly patients. Methods Ninety-four elderly patients with positive bacilli and pulmonary tuberculosis were enrolled in this study. Forty-six patients with fixed-dose combination therapy were treated with isoniazid (H), rifampicin (R), pyrazinamide (Z) 48 cases of ethambutol (E) as the control group. Two groups of recent sputum negative conversion, changes in chest X-ray lesions, adverse reactions and so on. Results At the end of the second month, the sputum smear negative conversion rate and culture negative conversion rate in the treatment group and the control group were 76.1% and 71.7%, 75.0% and 72.9% respectively. When the treatment was over 6 months, the sputum of the treatment group and the control group The film negative conversion rate and culture negative conversion rate were 89.1% and 91.3%, 89.6% and 89.6% respectively. Chest X-ray was significantly improved (absorption and absorption), the treatment group and control group lesions were 89.1% and 89.6%, respectively. The treatment group and the control group were 4 cases (8.7%), 5 cases (10.4%) of liver dysfunction. Conclusion The fixed dose of compound preparation and powder medicine have the same treatment effect and similar side effects, which is worthy of promotion and application in the treatment of elderly patients with pulmonary tuberculosis.