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目的:评价宫颈普通电刀锥切术(EKC)和宫颈环行电切除术(LEEP)治疗宫颈上皮内瘤变Ⅲ级(CINⅢ)的临床疗效。方法:回顾性分析我院2007年2月至2012年3月收治的139例CINⅢ患者的临床资料,比较两种手术方法治疗CINⅢ的临床疗效。结果:1两组术中出血量及手术时间相比,差异无统计学意义(P>0.05);2 EKC组锥切标本的锥高大于LEEP组,差异有高度统计学意义(P<0.01),EKC组宫颈内口切缘阳性率低于LEEP组,两组比较差异有高度统计学意义(P<0.01);3两组术后病灶的残留率比较EKC组低于LEEP组,差异有高度统计学意义(P<0.01);4术后病变复发率EKC组低于LEEP组,两组比较差异有统计学意义(P<0.05)。5 EKC组术后高危HPV持续感染率低于LEEP组,两组比较差异有高度统计学意义(P<0.01)。结论:EKC同样具有LEEP出血少,手术时间短的优点,而在标本大小、减少复发及高危HPV持续感染方面优于LEEP。
Objective: To evaluate the clinical efficacy of common cervical electric knife conization (EKC) and cervical ring excision (LEEP) in the treatment of cervical intraepithelial neoplasia grade Ⅲ (CIN Ⅲ). Methods: The clinical data of 139 patients with CIN Ⅲ who were treated in our hospital from February 2007 to March 2012 were retrospectively analyzed. The clinical efficacy of the two surgical methods in treating CIN Ⅲ was compared. Results: There was no significant difference between the two groups in the amount of bleeding and the operation time (P> 0.05). The cone height of conical specimens in 2 EKC group was significantly higher than that in LEEP group (P <0.01) (P <0.01). The residual rate of postoperative lesion in EKC group was lower than that in LEEP group, and the difference was highly significant Statistical significance (P <0.01) .4 The recurrence rate of postoperative lesion in EKC group was lower than that in LEEP group, the difference was statistically significant (P <0.05). The postoperative infection rate of high-risk HPV in EKC group was lower than that in LEEP group, the difference was statistically significant (P <0.01). Conclusions: EKC also has the advantages of less LEEP bleeding and shorter operation time, and is superior to LEEP in the aspects of specimen size, recurrence reduction and persistent high-risk HPV infection.