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在广泛使用中枢神经系统(CNS)预防疗法前,白血病儿童的脑部合并症常是脑膜白血病、病毒感染、血小板减少所致出血以及化疗药物毒性所致。自从使用强烈的化疗及早期CNS预防,虽使存活时间延长及脑膜白血病的发生率减少,却产生了一种新型的医源性脑病。作者观察了39例急性淋巴细胞性或未分化白血病患儿,年龄15岁以下,均获得首次6个月到6年的完全缓解。用电子计算机化的X线断层照片和颅骨X线照片检查他们的颅内钙化。结果,X线断层照片发现了10例有明显的颅内钙化,其中7例在颅骨X线照片上亦可见钙沉着。钙化呈点状或散射,常稀散呈斑点状。有7例为皮
Prior to the widespread use of central nervous system (CNS) prophylaxis, brain complications in children with leukemia are often associated with leukemia, viral infection, haemorrhage resulting from thrombocytopenia, and toxicities of chemotherapeutic drugs. Since the use of intensive chemotherapy and early CNS prophylaxis, a new type of iatrogenic encephalopathy has been developed despite prolonged survival and reduced incidence of meningo-leukemia. The authors looked at 39 patients with acute lymphoblastic or undifferentiated leukemia, under the age of 15 years, were the first complete 6 to 6 years of complete remission. Their intracranial calcifications were examined with computerized tomography and skull radiographs. Results, X-ray examination revealed 10 cases of significant intracranial calcification, of which 7 cases of calyx calcification in the skull can be seen. Calcification was spotted or scattered, often scattered spotted. There are 7 cases of skin