论文部分内容阅读
目的:探讨临床药师在抗菌药物临床应用管理中的作用。方法:选择2013年7月至2013年12月鹤山市人民医院患者420例,随机分为两组,每组210例,设定观察组为临床药师干预抗菌药物使用组,对照组为无干预使用抗菌素组,比较两组不合理用药情况、不良反应、住院时间以及抗菌药物使用频次排序前5位统计,同时对患者药物联用情况进行记录。结果:观察组不合理用药率16.7%少于对照组83.8%,不良反应发生率4.8%少于对照组21.0%,住院时间(4.01±0.85)d少于对照组(12.13±3.46)d,差异具有统计学意义(P<0.05);观察组青霉素类药物和第1、2代头孢菌素类药物使用率明显升高,而奥硝唑的使用频次明显减少;观察组一联、二联、三联用药分别为75.2%、20.0%、4.8%,对照组为53.8%、32.9%、13.3%,观察组较对照组一联用药多,二联、三联用药少,差异具有统计学意义(P<0.05)。结论:临床药师在抗菌药物临床应用管理中作用明显,有效提高住院治疗效率,减少不良反应,降低滥用抗生素现象发生率。
Objective: To explore the role of clinical pharmacists in the clinical management of antibacterials. Methods: 420 patients from July 2013 to December 2013 in Heshan City People’s Hospital were randomly divided into two groups (n = 210). The observation group was set as the clinical pharmacist intervention group and the control group was used without intervention Antibiotics group, compared the two groups of irrational drug use, adverse reactions, length of stay and antimicrobial frequency of use of the top 5 statistics, at the same time, the patient’s drug combination records. Results: The irrational drug use rate in the observation group was 16.7% less than that in the control group, 83.8% in the observation group, 4.8% in the adverse reaction group was less than 21.0% in the control group, 4.01 ± 0.85 days in the observation group was less than 12.13 ± 3.46 days in the control group, (P <0.05). The use rates of penicillins and first and second-generation cephalosporins in the observation group were significantly higher than those in the observation group, while the frequency of ornidazole was significantly decreased. The triple drug use was 75.2%, 20.0% and 4.8% respectively in the control group and 53.8%, 32.9% and 13.3% in the control group. The observation group had more drugs in combination with the control group than in the control group, and the difference was statistically significant (P < 0.05). Conclusion: Clinical pharmacists have obvious effect in the management of clinical application of antibacterial drugs, which can effectively improve the efficiency of hospitalization, reduce adverse reactions and reduce the incidence of abuse of antibiotics.