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目的探讨区域辅助化疗对肝癌根治术患者远期生存及转移复发的影响。方法选取2010年1月—2013年3月于九江学院附属医院行肝癌根治术的患者104例,按照是否接受区域辅助化疗分为研究组63例与对照组41例。研究组患者术后行药物输注系统区域辅助化疗,对照组患者术后未进行药物输注系统区域辅助化疗。观察两组患者转移复发率、术后生存率及毒副作用发生情况。结果研究组患者术后1、2、3、4年转移复发率低于对照组,生存率高于对照组,差异有统计学意义(P<0.05);研究组患者未出现严重毒副作用。结论区域辅助化疗可降低肝癌根治术患者转移复发率,延迟转移复发时间,提高患者生存率,且毒副作用少。
Objective To investigate the effect of regional adjuvant chemotherapy on long-term survival, metastasis and recurrence of patients with hepatocellular carcinoma after radical operation. Methods From January 2010 to March 2013, 104 patients undergoing radical resection of liver cancer in Jiujiang University Hospital were divided into study group (63 cases) and control group (41 cases) according to whether receiving regional adjuvant chemotherapy. Patients in the study group received regional adjuvant chemotherapy after drug infusion and patients in the control group received no adjuvant chemotherapy after the operation. The recurrence rate, postoperative survival rate and the incidence of side effects were observed. Results The recurrence rate of metastasis at 1, 2, 3 and 4 years after operation in study group was lower than that in control group, and the survival rate was higher than that in control group (P <0.05). There was no serious side effect in study group. Conclusions Regional adjuvant chemotherapy can reduce the recurrence and metastasis rate of patients with liver cancer, delay the time of metastasis and recurrence, improve the survival rate of patients with less side effects.