目的探讨ＴＮＦ－α和ＩＦＮ－γ在肝纤维化发病中的学意义。方法采用双抗体夹心ＥＬＩＳＡ法、放免法测定１１５例肝病、２０例健康成人血清ＴＮＦ－α、ＩＦＮ－γ及ＬＮ、ＰＣＩ、ＫⅢ水平。结果肝病组ＴＮＦ－ａ、ＩＦＮ－γ明显高于正常对照组（Ｐ＜０．０１）．而ＬＮ、ＰＣⅢ同步升高，ＰＣⅠ在急性肝炎、慢性肝炎（中重型）亦明显增高（Ｐ＜０．０１）。结论本组资料提示ＴＮＦ－α、ＩＦＮ－γ等细胞因子对肝纤维化具有调控作用。 Objective To investigate the significance of TNF-α and IFN-γ in the pathogenesis of hepatic fibrosis. Methods Serum levels of TNF-α, IFN-γ, LN, PCI and KⅢ in 115 cases of liver disease and 20 cases of healthy adults were determined by double antibody sandwich ELISA and radioimmunoassay. Results The levels of TNF-a and IFN-γ in liver disease group were significantly higher than those in normal control group (P <0.01). However, the levels of LN and PCⅢ increased synchronously, and PCⅠin acute hepatitis and chronic hepatitis were also significantly higher (P <0.01). Conclusion The data in this group suggest that cytokines such as TNF-α and IFN-γ may play a regulatory role in liver fibrosis.