论文部分内容阅读
将小鼠一侧颈总动脉和对侧椎动脉阻断（ ＢＨＩ－２Ａ）剩余脑血供籍 ｗｉｌｌｉｓ环进行重分配以模拟近似失血性休克（ＨＳ）的全脑低灌，分析其在ＨＳ过程中的意义。ＢＨＩ－２Ａ和ＨＳ组脑静脉血乳酸净变量均无明显变化。ＨＳ组的外周血乳酸和血糖均明显升高，二者均可被６５４－２所预防；ＢＨＩ－２Ａ的外周血乳酸明显降低而血糖变化不明显，降低的乳酸也可被预先应用６５个２所防止。ＢＮＩ－２Ａ ３０ｍｈ＋ＨＳ组的乳酸和血糖仍是ＨＳ的升高反应，但其幅度显著降低。ＳＨＩ－２Ａ和６５４－２对防止ＨＳ的血糖和乳酸升高有相似的抑制效应。ＨＳ组脑和肝组织的ＬＤＨ和ＣＰＫ均明显升高；ＢＨＩ－２Ａ时脑ＬＤＨ和肝ＣＰＫ不变，而脑的ＣＰＫ和肝的ＬＤＨ均显著降低，也表现出ＢＨＩ－２Ａ具有抑制效应。ＨＳ过程的脑低灌对休克具有保护性抑制效应。
The redistribution of the remaining cerebral blood supply to the willis ring by one side of the common carotid artery and the contralateral vertebral artery occlusion (BHI-2A) was simulated to simulate the whole brain hypoperfusion of hemorrhagic shock (HS) In the meaning. There was no significant change in the net blood lactate in BHI-2A and HS groups. Lactic acid and blood glucose in peripheral blood were significantly increased in HS group, both of which were prevented by 654-2; Lactate in peripheral blood of BHI-2A was significantly lower but blood glucose did not change significantly; decreased lactate could also be pre-applied 65 Prevent. Lactic acid and blood glucose levels in BNI-2A 30mh + HS group were still elevated in HS, but their amplitude was significantly decreased. SHI-2A and 654-2 have a similar inhibitory effect on the prevention of elevated blood glucose and lactate levels in HS. The levels of LDH and CPK in brain and liver were significantly increased in HS group. The brain LDH and CPK in BHI-2A were unchanged while the CPK and hepatic LDH in brain were significantly decreased, and also showed the inhibitory effect of BHI-2A. Brain hypoperfusion in HS has a protective inhibitory effect on shock.