消化道手术的术后感染率约为5%-10%,常以术后应用广谱抗生素预防。本研究比较了消化道手术病人术前与术后应用头孢美唑(CefmetazoIe)预防术后感染的效果。本试验病人共501例(胃十二指肠疾患229例、肝胆道疾病113例、小肠疾病18例、大肠疾病141例),年龄18-82岁,平均59.2岁。患者按术前(A组,314例)和术后(B组,187例)给药进行比较。A组从麻醉导入时或病人进入手术室时开始给予头孢美唑2g,每天2次,连续5天;B组从手术结束后开始给药,剂量疗程同A组。试验结果表明,从全身症状分析,A、B Postoperative infection rate of gastrointestinal surgery is about 5% -10%, often after the application of broad-spectrum antibiotics. This study compared the efficacy of cefmetazole in the prevention of postoperative infection in patients with gastrointestinal surgery before and after surgery. A total of 501 patients (229 cases of gastroduodenal disease, 113 cases of hepatobiliary disease, small intestinal disease in 18 cases, 141 cases of large intestine disease), aged 18-82 years, mean 59.2 years. Patients were compared preoperatively (Group A, 314 cases) and postoperative (Group B, 187 cases). Group A received cefmetazole 2 g twice daily for 5 days from the time of anesthesia induction or when the patient entered the operating room. Group B started administration from the end of the operation and the dosage was the same as that of group A. Test results show that from the systemic symptom analysis, A, B