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丙谷胺(proglumide,PGM)是胃泌素/胆囊收缩素受体拮抗剂,具有抑制胰腺分泌、胆囊收缩和对抗胃泌素/胆囊收缩素的营养作用等生物效应,在临床上,目前主要用于治疗消化性溃疡等胃疾病.关于PGM对胆汁分泌的影响国外尚无报道。本实验研究PGM对大鼠,狗和T管引流病人肝胆汁分泌以及对豚鼠胆石生成的影响。
Proglumide (proglumide, PGM) is a gastrin / cholecystokinin receptor antagonist, with the inhibition of pancreatic secretion, gallbladder contraction and antagonism of gastrin / cholecystokinin nutrition and other biological effects, in the clinic, the current main For the treatment of gastric diseases such as peptic ulcer.For the impact of PGM on bile secretion has not been reported abroad. This study investigated the PGM on rat, dog and T tube drainage of liver and gallbladder secretion of gallstone in guinea pigs.